Resolution:
## Figure 1.
Distribution and correlation of the LOH/CNV frequency values predicted by the HWE-based
and SI-based methods. (A) For 54,001 markers, the frequencies of copy loss (SI loss) and gain (SI gain)
were calculated based on signal intensities using the output from PennCNV analysis. Frequencies of copy loss (HWE loss) and gain (HWE gain) were calculated
based on a generalization of the Hardy-Weinberg principle for more than two allele
frequencies by considering an extra allele frequency. These frequencies are presented
as an overlay plot in which the X scale represents the 54,001 markers first sorted
by the SI loss values and then by chromosomal position. (B) Table describing the expected
signs for correlation between the methods for predicting CNV frequency. (C) Observed
correlations between these methods.
Seroussi |