Additional file 4.

Functional annotation of interacting proteins. Additional file 4 contains three tables (S7 to S9) listing the functional annotations of the PDZ domain interacting proteins. Supplemental Table S7: Concise description, GO terms and KOG (EuKaryotic Orthologous Groups), for each interacting protein when available, retrieved from Wormbase WS 190 [16]; note that most attributes are inferred from electronic annotation. Experimental Evidence Codes: EXP: Inferred from Experiment, IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction, IMP: Inferred from Mutant Phenotype, IGI: Inferred from Genetic Interaction, IEP: Inferred from Expression Pattern. Computational Analysis Evidence Codes: ISS: Inferred from Sequence or Structural Similarity, ISO: Inferred from Sequence Orthology, ISA: Inferred from Sequence Alignment, ISM: Inferred from Sequence Model, IGC: Inferred from Genomic Context, RCA: inferred from Reviewed Computational Analysis. Author Statement Evidence Codes: TAS: Traceable Author Statement, NAS: Non-traceable Author Statement. Curator Statement Evidence Codes: IC: Inferred by Curator, ND: No biological Data available. Automatically-assigned Evidence Codes: IEA: Inferred from Electronic Annotation. Supplemental Table S8: Classification of interacting proteins according to Cellular Components terms: integral to membrane, nucleus and other&unknown. Supplemental Table S9: Classification of interacting proteins according to Biological Processes: manual curation of annotations retrieved from Wormbase WS190 were used to define the 11 groups of processes shown in Figure 2.

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Lenfant et al. BMC Genomics 2010 11:671   doi:10.1186/1471-2164-11-671