Proposed mechanisms regulating promoter activities in the intergenic region of CRELD2 and ALG12 gene pair. Under ER stress conditions, ATF6 and NF-Y translocate into nucleus, form complex and specifically bind the ERSE motif to induce CRELD2 and ALG12 promoter activities. Three sites (I, II and III) in the intergenic region identified in this study are important for their basal promoter activities. However, factors binding to the site I, II and III could antagonize the ERSE-mediated up-regulation of both promoter activities cooperatively. According to the database of transcription regulatory motifs, the site II contains putative YY1- and MAZ-binding motifs and the site III contains an Ets family-binding motif, respectively.
Oh-hashi et al. BMC Genomics 2010 11:664 doi:10.1186/1471-2164-11-664