Open Access Research article

Skeletal muscle gene expression in response to resistance exercise: sex specific regulation

Dongmei Liu1, Maureen A Sartor2, Gustavo A Nader3, Laurie Gutmann4, Mary K Treutelaar5, Emidio E Pistilli6, Heidi B IglayReger1, Charles F Burant5, Eric P Hoffman7 and Paul M Gordon1*

Author Affiliations

1 Laboratory for Physical Activity and Exercise Intervention Research, Dept. of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA

2 Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA

3 Department of Medicine, Karolinski Institute, Stockholm, Sweden

4 Department of Neurology, West Virginia University, Morgantown, WV, USA

5 Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

6 Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA, USA

7 Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA

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BMC Genomics 2010, 11:659  doi:10.1186/1471-2164-11-659

Published: 24 November 2010

Additional files

Additional file 1:

Table S1: Gene concepts enriched with sex-related differential expression genes.

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Additional file 2:

Table S2: Significantly enriched biological concepts for up- and down-regulated genes in male biceps 4 h post-RE.

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Additional file 3:

Table S3: Enriched biological concepts for up- and down-regulated genes in male biceps 24 h post-RE.

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Additional file 4:

Table S4: Enriched biological concepts for up- and down-regulated genes in female biceps 4 h post-RE.

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Additional file 5:

Table S5: Enriched biological concepts for up- and down-regulated genes in female biceps 24 h post-RE.

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Additional file 6:

Table S6: Differential expression of the selected genes in exercised vs. rested muscle measured by qRT-PCR.

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Additional file 7:

Table S7: Key genes involved in RE-induced transcriptional regulation in male and female biceps branchii.

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Additional file 8:

Discussion on common GO terms and KEGGs pathways regulated by RE in both male and female biceps.

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Additional file 9:

Table S8: Genes for qRT-PCR validation and TaqMan assay used.

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