Table 4

Gene ontology (GO) categories significantly overrepresented (FDR, P < 0.001) in goat CNVRs.

GO level

GO term

Go name

No. in goat CNVRs

Expected no.


Molecular Function

GO:0005525

GTP binding

24

3.7

GO:0032561

guanyl ribonucleotide binding

24

3.8

GO:0003924

GTPase activity

16

2.1

GO:0019001

guanyl nucleotide binding

24

3.9

GO:0017111

nucleoside-triphosphatase activity

25

8.4

GO:0016462

pyrophosphatase activity

25

8.6

GO:0016818

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

25

8.6

GO:0016817

hydrolase activity, acting on acid anhydrides

25

8.8

GO:0015171

amino acid transmembrane transporter activity

6

0.50

GO:0004869

cysteine-type endopeptidase inhibitor activity

5

0.37

GO:0017076

purine nucleotide binding

37

19

GO:0046943

carboxylic acid transmembrane transporter activity

6

0.73

GO:0005342

organic acid transmembrane transporter activity

6

0.74

GO:0042974

retinoic acid receptor binding

3

0.094

GO:0046965

retinoid X receptor binding

3

0.094

GO:0022804

active transmembrane transporter activity

12

3.3

GO:0032553

ribonucleotide binding

37

18

GO:0032555

purine ribonucleotide binding

37

18

GO:0005275

amine transmembrane transporter activity

6

0.55

Biological processes

GO:0050896

response to stimulus

41

15

GO:0006952

defense response

16

2.6

GO:0006950

response to stress

25

8.0

GO:0051704

multi-organism process

13

2.2

GO:0046942

carboxylic acid transport

8

0.76

GO:0015849

organic acid transport

8

0.77

GO:0051707

response to other organism

10

1.5

GO:0009617

response to bacterium

9

1.1

GO:0042742

defense response to bacterium

7

0.68

Cellular components

GO:0042613

MHC class II protein complex

5

0.14

GO:0042611

MHC protein complex

7

0.62


The complete list of overrepresented GO and PANTHER categories is reported in Additional file 10 and Additional file 11, respectively, including details about the categories of the whole cattle genome (Btau_4.0 version) used as reference.

Fontanesi et al. BMC Genomics 2010 11:639   doi:10.1186/1471-2164-11-639

Open Data