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Open Access Research article

Integrated genomics of susceptibility to alkylator-induced leukemia in mice

Patrick Cahan and Timothy A Graubert*

Author Affiliations

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St. Louis, MO, USA

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BMC Genomics 2010, 11:638  doi:10.1186/1471-2164-11-638

Published: 17 November 2010

Additional files

Additional file 1:

Supplementary Table S1. SNP-derived haplotype blocks in 48 inbred mouse strains.

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Additional file 2:

Dendrograms showing clustering of strains by gene expression profile or SNP-derived haplotype blocks. (A) Unsupervised clustering of strains using the strain median expression profile in KL cells groups strains by t-AML susceptibility status to an extent greater than expected by chance (see text), and differently than when clustering gene expression profiles of the hypothalamus (B), adipose tissue (C), or when clustering based on SNP-based distance (D).

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Additional file 3:

Heatmap of genes differentially expressed in KL cells from t-AML susceptible vs. resistant strains of mice. 917 genes (976 probes) are differentially expressed between t-AML susceptible (SWR/J, DBA2/J, PL/J, AKR/J, BALB/cByJ) and t-AML resistant (C58/J, C57/J, FVB/J, C57BL/6J, A/J, NZB/J, C3H/HeJ, SJL/J, and 129S1/SvImJ) mice.

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Additional file 4:

Supplementary Table S2. Annotation of genes differentially expressed between t-AML susceptible and resistant strains of mice.

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Additional file 5:

Unsupervised clustering of expression profiles of purified hematopoietic compartments. BXD populations are indicated by the enriched population: erythrocytes (Ter119+, orange), myeloid lineage (Gr1+,green), hematopoietic stem cells (Lineage-Kit+Sca1+, red), and progenitors (Lineage-Kit+Sca1-, blue). Hematopoietic stem and progenitors from classical inbred strains are indicated by inbred strain name (Lineage-cKit+, navy blue). Each population forms a distinct cluster, with KL cells grouping most closely with stem and progenitor cells.

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