Table 4

Top five canonical pathways associated with each gene cluster following infestation with P. ovis

Temporal cluster*

Canonical Pathway

p-valueA


Cluster 1

p38 MAPK signalling

2.9E-05

IL12 signalling and production in macrophages

5.4E-05

IL10 signalling

6.9E-05

Aryl hydrocarbon receptor signalling

1.3E-04

PPAR signalling

2.9E-04

Cluster 2

IL10 signalling

1.2E-10

Production of nitric oxide and reactive oxygen species in macrophages

1.0E-09

Dendritic cell maturation

1.8E-09

TREM1 signalling

1.8E-09

NF-kB signalling

6.7E-09

Cluster 3

T helper cell differentiation

6.4E-08

IL10 signalling

3.7E-06

NF-kB signalling

1.6E-05

Acute phase response signalling

6.1E-05

TREM1 signalling

2.4E-04

Cluster 4

Interferon signalling

1.3E-05

Leukocyte extravasation signalling

2.9E-05

Antigen presentation pathway

3.9E-05

T helper cell differentiation

1.7E-04

CD28 signalling in T helper cells

1.9E-04

Cluster 6

Complement system

5.3E-12

Role of pattern recognition receptors in recognition of bacteria and viruses

2.9E-06

Acute phase response signalling

8.7E-05

Role of macrophages, fibroblasts and endothelial cells in RA#

1.0E-03

Wnt/beta-catenin signalling

2.3E-02

Cluster 7

Aryl hydrocarbon receptor signalling

3.5E-03

Antiproliferative role of somatostatin receptor 2

7.1E-03

CCR5 signalling in macrophages

3.8E-02

Integrin signalling

5.8E-02

IL1 signalling

7.7E-02

Cluster 8

Tight junction signalling

2.4E-03

BMP signalling pathway

2.3E-02

TGF beta signalling

2.8E-02

IL6 signalling

3.8E-02

Wnt/beta-catenin signalling

5.1E-02


Key - *Cluster 5 contained too few genes for effective analysis of canonical pathways. #Rheumatoid arthritis. Ap-value calculated using Fisher's exact test determining the probability that association between genes in the data set and canonical pathway is due to chance alone

Burgess et al. BMC Genomics 2010 11:624   doi:10.1186/1471-2164-11-624

Open Data