Table 1

Identification of sex-biased genes in five tissues

# Arrays

# Genes

# Genes on Sex Chr

Tissue

Females

Males

Total

Female up

Male up

X Obs

X Exp

p

Y Obs

Y Exp

p





A. Striatum

43

43

173

35

138

15

6.3

*

4

0.29

*

Neocortex

43

43

19

9

10

7

0.66

**

8

0.03

***





B. Hippocampus

60

60

12

8

4

8

0.4

***

4

0.008

***

Eye

60

60

31

21

10

12

1

***

5

0.021

***

Lung

22

22

160

101

59

16

5.4

**

5

0.11

***

Total

228

228


A: Tissues analysed using Illumina 6v1.1 platform.

B: Tissues analysed using Affymetrix M430v2.0 platform.

# Arrays: Number of arrays used for each tissue and sex.

# Genes: Number of significant sex-biased genes in each tissue and sex. Selection criteria: Wilcoxon Mann-Whitney test followed by Benjamini-Hochberg (B-H) correction for multiple testing. B-H adjusted threshold p ≤ 0.05. Unannotaded probes and gene-probe redundancies are not included in these numbers; Additional file 1 includes all significant probes and raw p-values.

# Genes on Sex Chr: Observed number of genes on the sex chromosomes and expected numbers when "# Genes Total" are drawn from the array. Asterisks denote that X- and Y-linkage is statistically overrepresented among sex-biased genes according to Fisher's exact test. p-values: * ≤ 1E-3, ** ≤ 1E-10, *** ≤ 1E-15.

Reinius et al. BMC Genomics 2010 11:614   doi:10.1186/1471-2164-11-614

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