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Open Access Research article

Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

Bladimir J Ovando1, Corie A Ellison1, Chad M Vezina2 and James R Olson1*

Author Affiliations

1 Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214, USA

2 School of Pharmacy and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA

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BMC Genomics 2010, 11:583  doi:10.1186/1471-2164-11-583

Published: 19 October 2010

Additional files

Additional file 1:

Rat primer sequences used for real-time qPCR analysis. Oligonucleotide sequences for the forward and reverse primers used for real-time qPCR.

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Additional file 2:

Microarray gene expression following 52 weeks of chronic p.o. exposure to 30 ng/kg/day PCB126 A list of the 52 genes differentially expressed following 52 weeks of chronic exposure to 30 ng/kg/day PCB126. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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Additional file 3:

Microarray gene expression following 52 weeks of chronic p.o. exposure to 300 ng/kg/day PCB126 A list of the 128 genes differentially expressed following 52 weeks of chronic exposure to 300 ng/kg/day PCB126. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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Additional file 4:

Microarray gene expression following 52 weeks of chronic p.o. exposure to 1000 ng/kg/day PCB126 A list of the 216 genes differentially expressed following 52 weeks of exposure to 1000 ng/kgday PCB126. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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Additional file 5:

Microarray gene expression following 13 weeks of subchronic p.o. exposure to 100 ng/kg/day TCDD A list of the 103 genes differentially expressed following 13 weeks of subchronic exposure to 100 ng/kg/day TCDD. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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Additional file 6:

Microarray gene expression following 52 weeks of chronic p.o. exposure to 100 ng/kg/day TCDD A list of the 299 genes differentially expressed genes following 52 weeks of chronic exposure to 100 ng/kg/day TCDD. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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Additional file 7:

Microarray gene expression following 13 weeks of subchronic p.o. exposure to 1000 ng/kg/day PCB126 A list of the 371 genes differentially expressed genes following 13 weeks of subchronic exposure to 1000 ng/kg/day PCB126. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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Additional file 8:

Microarray gene expression following 13 weeks of subchronic p.o. exposure to 1000 μg/kg/day PCB153 A list of the 39 genes differentially expressed following 13 weeks of subchronic exposure to 1000 μg/kg/day PCB153. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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Additional file 9:

Microarray gene expression following 52 weeks of chronic p.o. exposure to 1000 μg/kg/day PCB153 A list of the 47 genes differentially expressed following 52 weeks of chronic exposure to 1000 μg/kg/day PCB153. A gene was considered to be differentially expressed if it displayed a gene expression fold change of 2 or greater.

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