Variance inflation due to correlation of gene expression increases the false positive rate, even when using a Bonferroni correction. The percentage of permutations in which at least one GO Biological Process category was called significant is shown versus the variance of the gene set statistic, for two human (a,b) and two mouse (c,d) arrays. Spearman correlations are in the upper left of each panel.
Gatti et al. BMC Genomics 2010 11:574 doi:10.1186/1471-2164-11-574