Enrichment of high-scoring eQTL for mutant expression changes. We used large-scale loss-of-function gene expression studies in yeast to determine whether high-scoring eQTL were near genes that, when mutated, perturbed the expression of the target gene. All methods showed significant enrichment for eQTL causing large expression changes when genes proximal to the eQTL are mutated, though the degree of enrichment varied widely. RFSF showed the most significant enrichment with P = 1.03 × 10-99.
Michaelson et al. BMC Genomics 2010 11:502 doi:10.1186/1471-2164-11-502