Relationship between sample size and ability to recover biologically relevant loci. Subsets of decreasing size (67, 34, 17, and 10 strains) were taken from the hippocampus eQTL study and eQTL were mapped using RFSF and HK. Performance was evaluated with the cis-eQTL and KEGG enrichment benchmarks. Both RFSF and HK improved performance when additional strains were added, though the performance RFSF was consistently better than HK in both benchmarks for all sample sizes.
Michaelson et al. BMC Genomics 2010 11:502 doi:10.1186/1471-2164-11-502