late phase repression of target genes in a strain with an inducible NDT80. repression level of common and Ndt80-only targets (difference between middle and late time points) is presented as a color coded heat-map in WT, Ndt80-ER and sum1Δ backgrounds. Note that in Ndt80-only targets WT and ER samples are significantly different, while in the common targets the repression pattern is similar. Both groups show same level of induction in the sum1Δ strain indicating that the repression of all those genes is Sum1 dependent. The metric (see Methods) capturing the relative contribution of the indirect edge in the repression of the target genes in the common group is shown with a blue color code. Note presence of genes with large weight as well as genes with small weight values in the common targets.
Klutstein et al. BMC Genomics 2010 11:478 doi:10.1186/1471-2164-11-478