Table 5 |
|||||
|
Summary of TF connectivity |
|||||
|
TFBS |
Total Connectivity |
C1 |
C2 |
C28 |
TF in Lung |
|
|
|||||
|
CEBP |
447 |
238 |
51 |
158 |
Cebpa, Cebpb, Cebpd, Cebpg |
|
|
|||||
|
IRFF |
404 |
239 |
0 |
165 |
Irf1, Irf2, Irf3, Irf5, Irf7 |
|
|
|||||
|
HNF3 |
359 |
228 |
51 |
80 |
Foxa1, Foxa2 |
|
|
|||||
|
GATA |
358 |
218 |
44 |
96 |
Gata6, Gata1 |
|
|
|||||
|
ETSF |
344 |
172 |
14 |
158 |
Ets1, Ets2, Etv5, Nfe2l2, Elf2 |
|
|
|||||
|
SREB |
312 |
162 |
43 |
107 |
Srebf1 |
|
|
|||||
|
FOXO |
268 |
151 |
0 |
117 |
Foxo1, Foxo4, Foxo3a |
|
|
|||||
|
FKHD |
213 |
95 |
25 |
93 |
Foxf2, Foxc1 |
|
|
|||||
|
HAND |
201 |
94 |
0 |
107 |
Lmo2 |
|
|
|||||
|
STAT |
182 |
0 |
0 |
182 |
Stat6, Stat3 |
|
|
|||||
|
MEF2 |
176 |
110 |
0 |
66 |
Mef2a |
|
|
|||||
|
NFAT |
169 |
0 |
0 |
169 |
Ilf3, Nfatc3 |
|
|
|||||
|
CP2F |
168 |
83 |
0 |
85 |
Atf4, Tcfcp2, Atf3, Atf1 |
|
|
|||||
|
NFKB |
166 |
78 |
0 |
88 |
Nfkb1 |
|
|
|||||
|
EREF |
165 |
113 |
0 |
52 |
Esrra |
|
|
|||||
|
LEFF |
150 |
97 |
0 |
53 |
Lef1 |
|
|
|||||
|
HFH |
134 |
75 |
19 |
40 |
Foxf1a, Foxi1 |
|
|
|||||
|
PARF |
134 |
134 |
0 |
0 |
Tef, Tead1 |
|
|
|||||
|
AP1R |
129 |
60 |
0 |
69 |
Nfe2 |
|
|
|||||
|
LEFF |
121 |
87 |
34 |
0 |
Tcf4 |
|
|
|||||
|
CIZF |
117 |
117 |
0 |
0 |
Znf384 |
|
|
|||||
|
HAND |
113 |
43 |
0 |
70 |
Tcf12 |
|
|
|||||
|
BARBIE |
111 |
98 |
13 |
0 |
Unknown |
|
|
|||||
|
NKXH |
106 |
68 |
38 |
0 |
Nkx2-1 |
|
|
|||||
|
SORY |
104 |
93 |
11 |
0 |
Sox5, Sox9 |
|
|
|||||
|
NR2F |
98 |
37 |
20 |
41 |
Hnf4a, Nr2f1, Nr2f2 |
|
|
|||||
|
OCT |
92 |
92 |
0 |
0 |
Pou2f1, Pou6f2 |
|
|
|||||
|
CREB |
79 |
0 |
10 |
69 |
Creb1 |
|
|
|||||
|
MYOD |
74 |
0 |
0 |
74 |
Myog |
|
|
|||||
|
NKX7 |
62 |
39 |
0 |
23 |
Nkx6-2 |
|
|
|||||
|
EBOX |
59 |
0 |
21 |
38 |
Tcf4, Max |
|
|
|||||
|
P53F |
57 |
0 |
0 |
57 |
Trp53 |
|
|
|||||
|
RORA |
57 |
0 |
0 |
57 |
Rora |
|
|
|||||
|
HAML |
54 |
0 |
0 |
54 |
Runx2, Pebp1 |
|
|
|||||
|
RXRF |
54 |
0 |
0 |
54 |
Nr1h2 |
|
|
|||||
|
GREF |
48 |
48 |
0 |
0 |
Nr3c1 |
|
|
|||||
|
BRN5 |
46 |
25 |
0 |
21 |
Pou6f1 |
|
|
|||||
|
HESF |
46 |
0 |
20 |
26 |
Hes1 |
|
|
|||||
|
EGRF |
45 |
0 |
45 |
0 |
Egr1, Wt1 |
|
|
|||||
|
HOXH |
44 |
0 |
0 |
44 |
Meis1 |
|
|
|||||
|
SPIF |
39 |
0 |
39 |
0 |
Klf11 |
|
|
|||||
|
HNF1 |
38 |
0 |
38 |
0 |
Hnf1a, Hnf1b, Hmbox1 |
|
|
|||||
|
E2FF |
33 |
0 |
33 |
0 |
E2f1, E2f2, E2f3, E2f4, E2f5, E2f7 |
|
|
|||||
|
SMAD |
23 |
0 |
23 |
0 |
Smad4 |
|
|
|||||
|
ZBPF |
23 |
0 |
23 |
0 |
Zfp219 |
|
|
|||||
|
NKX6 |
22 |
22 |
0 |
0 |
Nkx6-1 |
|
|
|||||
|
LXHF |
21 |
21 |
0 |
0 |
Lxh3 |
|
|
|||||
|
AP2F |
19 |
0 |
19 |
0 |
Tcfap2c |
|
|
|||||
|
PTBP |
19 |
0 |
19 |
0 |
Tbp |
|
|
|||||
|
GLIF |
16 |
0 |
16 |
0 |
Zic2 |
|
|
|||||
|
BCDF |
15 |
0 |
15 |
0 |
Crx |
|
|
|||||
|
SPZ1 |
11 |
0 |
11 |
0 |
Spz1 |
|
|
|||||
|
PAX2 |
10 |
0 |
10 |
0 |
Pax2 |
|
|
|||||
|
MTF1 |
9 |
0 |
9 |
0 |
Mtf1 |
|
|
|||||
|
ZF5F |
8 |
0 |
8 |
0 |
Zfp161 |
|
|
|||||
|
We calculated the confidence score based on the integrative evidence of TF-TG relationship. Using the cut off confidence score of 0.5, the overall connectivity of each TF to its potential TGs within three clusters were calculated and summarized in Table 5. The corresponding TFs expressed in lung were also listed. |
|||||
|
Xu et al. BMC Genomics 2010 11:451 doi:10.1186/1471-2164-11-451 |
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