Table 5

Summary of TF connectivity

TFBS

Total Connectivity

C1

C2

C28

TF in Lung


CEBP

447

238

51

158

Cebpa, Cebpb, Cebpd, Cebpg


IRFF

404

239

0

165

Irf1, Irf2, Irf3, Irf5, Irf7


HNF3

359

228

51

80

Foxa1, Foxa2


GATA

358

218

44

96

Gata6, Gata1


ETSF

344

172

14

158

Ets1, Ets2, Etv5, Nfe2l2, Elf2


SREB

312

162

43

107

Srebf1


FOXO

268

151

0

117

Foxo1, Foxo4, Foxo3a


FKHD

213

95

25

93

Foxf2, Foxc1


HAND

201

94

0

107

Lmo2


STAT

182

0

0

182

Stat6, Stat3


MEF2

176

110

0

66

Mef2a


NFAT

169

0

0

169

Ilf3, Nfatc3


CP2F

168

83

0

85

Atf4, Tcfcp2, Atf3, Atf1


NFKB

166

78

0

88

Nfkb1


EREF

165

113

0

52

Esrra


LEFF

150

97

0

53

Lef1


HFH

134

75

19

40

Foxf1a, Foxi1


PARF

134

134

0

0

Tef, Tead1


AP1R

129

60

0

69

Nfe2


LEFF

121

87

34

0

Tcf4


CIZF

117

117

0

0

Znf384


HAND

113

43

0

70

Tcf12


BARBIE

111

98

13

0

Unknown


NKXH

106

68

38

0

Nkx2-1


SORY

104

93

11

0

Sox5, Sox9


NR2F

98

37

20

41

Hnf4a, Nr2f1, Nr2f2


OCT

92

92

0

0

Pou2f1, Pou6f2


CREB

79

0

10

69

Creb1


MYOD

74

0

0

74

Myog


NKX7

62

39

0

23

Nkx6-2


EBOX

59

0

21

38

Tcf4, Max


P53F

57

0

0

57

Trp53


RORA

57

0

0

57

Rora


HAML

54

0

0

54

Runx2, Pebp1


RXRF

54

0

0

54

Nr1h2


GREF

48

48

0

0

Nr3c1


BRN5

46

25

0

21

Pou6f1


HESF

46

0

20

26

Hes1


EGRF

45

0

45

0

Egr1, Wt1


HOXH

44

0

0

44

Meis1


SPIF

39

0

39

0

Klf11


HNF1

38

0

38

0

Hnf1a, Hnf1b, Hmbox1


E2FF

33

0

33

0

E2f1, E2f2, E2f3, E2f4, E2f5, E2f7


SMAD

23

0

23

0

Smad4


ZBPF

23

0

23

0

Zfp219


NKX6

22

22

0

0

Nkx6-1


LXHF

21

21

0

0

Lxh3


AP2F

19

0

19

0

Tcfap2c


PTBP

19

0

19

0

Tbp


GLIF

16

0

16

0

Zic2


BCDF

15

0

15

0

Crx


SPZ1

11

0

11

0

Spz1


PAX2

10

0

10

0

Pax2


MTF1

9

0

9

0

Mtf1


ZF5F

8

0

8

0

Zfp161


We calculated the confidence score based on the integrative evidence of TF-TG relationship. Using the cut off confidence score of 0.5, the overall connectivity of each TF to its potential TGs within three clusters were calculated and summarized in Table 5. The corresponding TFs expressed in lung were also listed.

Xu et al. BMC Genomics 2010 11:451   doi:10.1186/1471-2164-11-451

Open Data