Table 3

Clusters Feature Comparison

Cluster name

Gene Number

Function and Process

Mouse Phenotype

Cell Components


C1

313

Lipid biosynthesis; Morphogenesis; Differentiation; Proliferation; Lung and respiratory tube development; Vascular development

Abnormal vasculature development; Abnormal cardiovascular physiology; Abnormal alveolar morphology; Abnormal respiratory mechanics

Insoluble fraction; Membrane fraction


C2

54

Lipid Metabolism; Lipid Transport

Abnormal respiratory alveolar morphology; Abnormal lipid homeostasis

Endoplasmic reticulum


C28

205

Response to external stimulus; Lipid metabolic process

Abnormal blood chemistry

Insoluble fraction; Integral to plasma membrane


Genes from each cluster were subject to gene set enrichment analysis to identify enriched functions and processes, mouse phenotypes and cell components http://toppgene.cchmc.org/ webcite.

Xu et al. BMC Genomics 2010 11:451   doi:10.1186/1471-2164-11-451

Open Data