Open Access Highly Accessed Research article

Development of admixture mapping panels for African Americans from commercial high-density SNP arrays

Guanjie Chen1, Daniel Shriner1, Jie Zhou1, Ayo Doumatey1, Hanxia Huang1, Norman P Gerry2, Alan Herbert3, Michael F Christman2, Yuanxiu Chen4, Georgia M Dunston4, Mezbah U Faruque4, Charles N Rotimi1 and Adebowale Adeyemo1*

Author Affiliations

1 Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 USA

2 Coriell Institute for Medical Research, Camden, NJ 08103 USA

3 Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts 02118 USA

4 National Human Genome Center, Howard University, Washington DC 20060 USA

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BMC Genomics 2010, 11:417  doi:10.1186/1471-2164-11-417

Published: 5 July 2010

Additional files

Additional file 1:

Markers in the panel based on δ. δ, FST, and SIC values for AIMS in the panel based on δ.

Format: XLS Size: 374KB Download file

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Additional file 2:

Markers in the panel based on FST. δ, FST, and SIC values for AIMS in the panel based on FST.

Format: XLS Size: 348KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 3:

Markers in the 2 k and 21 k random marker panels. δ, FST, and SIC values for AIMS in the panel based on 2 k and 21 k random marker panels.

Format: XLS Size: 3.6MB Download file

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Additional file 4:

Multidimensional scaling plot. Top four dimensions from multidimensional scaling plot showing HUFS in blue circles, CEU in red squares, and YRI in green diamonds.

Format: DOC Size: 102KB Download file

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Additional file 5:

Inter-marker genetic distances (excluding centromeres). Average inter-marker distances in the panels based on δ, FST, 2 k, and 21 k random marker.

Format: DOC Size: 59KB Download file

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Additional file 6:

Distributions of δ, FST, and SIC for the AIMs panels. Genome-wide distributions of δ, FST, and SIC values for AIMS. Red represents values from the panel based on δ, blue represents values from the panel based on FST, and dark green represents values from the panel of 21 k random markers. Top) δ values. Middle) FST values. Bottom) SIC values.

Format: DOC Size: 597KB Download file

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