Open Access Research article

Deletions of Immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia

Elisabeth P Nacheva1*, Diana Brazma1, Anna Virgili1, Julie Howard-Reeves1, Anastasios Chanalaris1, Katya Gancheva2, Margarita Apostolova2, Mikel Valgañon1, Helen Mazzullo1 and Colin Grace1

Author Affiliations

1 UCL School of Medicine, Cancer Institute, Academic Haematology, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF, UK

2 Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria

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BMC Genomics 2010, 11:41  doi:10.1186/1471-2164-11-41

Published: 18 January 2010

Additional files

Additional file 1:

Figure S1. Active genome loci in cml.

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Additional file 2:

Table S1. Id number, sex and disease stage of the 92 cml samples.

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Additional file 3:

Additional Figure 2. Observed vs expected values of delta (Δ) for ~100,000 probes.

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Additional file 4:

Additional Table 2. Annotated flourescence ratio data for 105 k arrays: Listing of probes, locations, gene assignments, lineage, gender and sample identifiers.

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Additional file 5:

Figure S3. Mapping of igh deletions at average 1 kb resolution.

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Additional file 6:

Figure S4. Mapping of tcr gamma deletions at verage 1 kb resolution.

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Additional file 7:

Figure S5. THE IGH GENE COMPLEX.

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Additional file 8:

Figure S6. The TCRG gene complex.

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Additional file 9:

Table S3. Immunophenotype and karyotype data for 27 samples from patients in blast crisis of cml.

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Additional file 10:

Figure S7. Representative array cgh profiles of concomitant loss of chromosomes 7 and 9 in cml lymphoid blast crisis.

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Additional file 11:

Figure S8. Representative array cgh profiles of cml/bcl cases with intact ikaros.

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Additional file 12:

Table S4. Sample data for 5 cases with lymphoid blast crisis.

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