Open Access Research article

Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

Raoul Frijters1, Wilco Fleuren1, Erik JM Toonen3, Jan P Tuckermann5, Holger M Reichardt6, Hans van der Maaden4, Andrea van Elsas3, Marie-Jose van Lierop3, Wim Dokter3, Jacob de Vlieg12 and Wynand Alkema2*

Author Affiliations

1 Computational Drug Discovery (CDD), Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, the Netherlands

2 Department of Molecular Design & Informatics, Schering-Plough, Molenstraat 110, 5342 CC Oss, the Netherlands

3 Department of Immunotherapeutics, Schering-Plough, Molenstraat 110, 5342 CC Oss, the Netherlands

4 Molecular Pharmacology Department, Schering-Plough, Molenstraat 110, 5342 CC Oss, the Netherlands

5 Tuckermann Lab, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena, Germany

6 Department of Cellular and Molecular Immunology, University of Göttingen Medical School, Humboldtallee 34, 37073 Göttingen, Germany

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BMC Genomics 2010, 11:359  doi:10.1186/1471-2164-11-359

Published: 5 June 2010

Additional files

Additional file 1:

Differentially regulated probe sets in liver of prednisolone-treated versus vehicle-treated wild type mice. Prednisolone treatment resulted in a significant differential regulation of 518 probe sets in wild type mice (347 upregulated and 171 downregulated; p-value < 0.01). The table shows the Affymetrix probe set identifiers of the differentially regulated probe sets, full gene names, gene symbols and the fold changes.

Format: XLS Size: 154KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 2:

Differentially regulated probe sets in liver of prednisolone-treated versus vehicle-treated GRdimmice. Prednisolone treatment resulted in a significant differential regulation of 34 probe sets in GRdim mice (29 upregulated and 5 downregulated; p-value < 0.01). The table shows the Affymetrix probe set identifiers of the differentially regulated probe sets, full gene names, gene symbols and the fold changes.

Format: XLS Size: 23KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data