Table 3

Differentially regulated genes involved in G2-M phase transition.

Symbol

Gene Name

Wt

Xpc-/-


Arl4*

ADP-ribosylation factor-like 4

1.15

1.20

Asf1b*

ASF1 anti-silencing function 1 homolog B

1.24

1.25

Ccnb2

cyclin B2

-1.24

-1.16

Cdc25c

cell division cycle 25 homolog C (S. cerevisiae)

-1.09

-1.30

Cdc42ep4

CDC42 effector protein (Rho GTPase binding) 4

1.33

1.29

Cdca8

cell division cycle associated 8

-1.24

-1.11

Cit*

citron

1.20

1.35

Cks2*

CDC28 protein kinase regulatory subunit 2

1.29

1.36

Ect2*

ect2 oncogene

1.25

1.45

Got1

glutamate oxaloacetate transaminase 1, soluble

1.24

1.24

Gpsm2*

G-protein signalling modulator 2 (AGS3-like)

1.23

1.33

Kpna2

karyopherin (importin) alpha 2

1.35

1.30

Map3k6*

mitogen-activated protein kinase kinase kinase 6

1.25

1.35

Psip1*

PC4 and SFRS1 interacting protein 1

1.17

1.30

Rrm1*

ribonucleotide reductase M1

1.18

1.22

Tacc3*

transforming, acidic coiled-coil containing protein 3

1.31

1.34

Tdp1

tyrosyl-DNA phosphodiesterase 1

1.28

1.21

Tubd1*

tubulin, delta 1

1.26

1.30


Gene expression ratios are presented of 18 differentially regulated genes involved in G2 to M phase transition based on microarray results. These 18 genes, of which 3 were down regulated and 15 were up regulated after B[a]P exposure, showed a trend towards a more pronounced induction in Xpc-/- mice as compared to Wt mice (p = 0.086). However, a less extensive down regulation is not the same as a greater induction. Therefore, an additional p-value was calculated for the 15 up regulated genes, showing that 11 (indicated with *) out of these 15 up regulated genes are more induced in Xpc-/- than in Wt mice (p = 0.024).

Verhofstad et al. BMC Genomics 2010 11:333   doi:10.1186/1471-2164-11-333

Open Data