Open Access Research article

Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice

Nicole Verhofstad1, Jeroen LA Pennings2, Conny ThM van Oostrom2, Jan van Benthem2, Frederik J van Schooten1, Harry van Steeg2 and Roger WL Godschalk1*

Author Affiliations

1 Department of Health Risk Analysis and Toxicology, School for Nutrition, Toxicology and Metabolism, Maastricht University, PO box 616, 6200 MD Maastricht, the Netherlands

2 Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), PO box 1, 3720 BA Bilthoven, the Netherlands

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BMC Genomics 2010, 11:333  doi:10.1186/1471-2164-11-333

Published: 26 May 2010

Additional files

Additional file 1:

Processes enriched among B[a]P induced genes. The data presented are terms enriched among the B[a]P induced gene list by DAVID/EASE with an FDR < 0.1.

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Additional file 2:

Processes enriched among B[a]P suppressed genes. The data presented are terms enriched among the B[a]P suppressed gene list by DAVID/EASE with an FDR < 0.1.

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Additional file 3:

Processes affected by B[a]P exposure in mouse testis. The data presented are terms enriched among the B[a]P modulated gene list by DAVID/EASE with an FDR < 0.1.

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Additional file 4:

Differentially regulated genes after B[a]P exposure involved in Chromatin structure. 37 differentially regulated genes involved in Chromatin structure. Results are presented as average gene expression ratios between exposed and control samples.

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Additional file 5:

Differentially regulated genes after B[a]P exposure regulating Spermatogenesis. 32 differentially regulated genes involved in Spermatogenesis. Results are presented as average gene expression ratios between exposed and control samples.

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Additional file 6:

Differentially regulated genes after B[a]P exposure involved in Translation. 59 differentially regulated genes involved in Translation. Results are presented as average gene expression ratios between exposed and control samples.

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Additional file 7:

Differentially regulated genes after B[a]P exposure involved in Mitochondrial function. 51 differentially regulated genes involved in mitochondrial function. Results are presented as average gene expression ratios between exposed and control samples. *genes involved in oxidative phosphorylation.

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