Open Access Highly Accessed Research article

Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation

Zhengyuan Wang1, Sahar Abubucker1, John Martin1, Richard K Wilson1, John Hawdon2 and Makedonka Mitreva1*

Author Affiliations

1 The Genome Center, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA

2 Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA

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BMC Genomics 2010, 11:307  doi:10.1186/1471-2164-11-307

Published: 14 May 2010

Additional files

Additional file 1:

Coverage of the A. caninum transcriptome based on low copy number conserved eukaryotic genes.

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Additional file 2:

The top 20 most abundant stage-specific and constantly expressed A. caninum genes.

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Additional File 3:

Stage-biased differential expression of A. caninum genes. A). Comparison among preparasitic and parasitic larval stages, and parasitic larval and adult stage. B) Comparison of expression profiles generated by suppression subtractive hybridization and cDNA sequencing of stage-specific libraries.

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Additional file 4:

Functional enrichment and depletion score derived from the enrichment and depletion probabilities calculated by hypogeometrics test of molecular functional GO terms.

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Additional file 5:

The top 10 most abundant stage-specific and constantly expressed A. caninum genes having homology to B. malayi but not C. elegans.

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Additional file 6:

Putative A.caninum parasitic genes and their functions.

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