Table 3

Top 20 brain-specific genes.

Entrez GeneID

Consolidated Rank

Rosetta1 MAX

Rosetta2 MAX

Stanford MAX

Genealtas MAX

Locuslink Symbol

Description


2670

1

5.25

4.90

5.02

3.48

GFAP

Glial fibrillary acidic protein, a major intermediate filament proteins of astrocytes

11075

2

4.57

4.45

4.53

5.04

STMN2

Stathmin-like 2, a neuronal growth-associated protein

2596

3

6.38

5.69

4.16

2.75

GAP43

Growth associated protein 43, regulates growth of axons during development and regeneration

4747

4

4.86

3.47

3.33

3.75

NEFL

Neurofilament, light polypeptide, a major constituent of the axoskeleton

5354

5

5.13

2.72

4.30

4.45

PLP1

Proteolipid protein 1, predominant myelin protein present in CNS

5375

6

4.47

4.95

2.97

2.09

PMP2

Peripheral myelin protein 2

9568

7

3.41

3.89

4.25

2.19

GABBR2

Gamma-aminobutyric acid (GABA) B receptor 2

9118

8

4.06

4.02

3.24

1.79

INA

Internexin neuronal intermediate filament protein alpha

1759

9

3.24

3.35

2.93

2.69

DNM1

Dynamin 1, involved in clathrin-mediated endocytosis

6456

10

3.57

3.45

2.46

2.51

SH3GL2

SH3-domain GRB2-like 2, Endophilin 1, mediator of synaptic vesicle formation

6616

11

5.54

3.25

1.52

4.17

SNAP25

Synaptosomal-associated protein 25 kDa, a SNARE protein required for neuronal exocytosis

29114

12

4.10

3.09

3.80

2.00

NP22

Neural protein 22

4155

13

5.10

3.46

1.30

4.79

MBP

Myelin basic protein, major constituent of myelin sheath of oligodendrocytes and Schwann

11076

14

2.67

3.43

2.84

2.27

TPPP

Tubulin polymerization promoting protein

6285

15

2.87

2.21

3.54

3.64

S100B

S100 calcium binding protein B, glial-derived protein serving as neurotrophic factor and neuronal survival protein

4741

16

2.97

2.78

2.55

2.52

NEFM

Neurofilament, medium polypeptide 150 kDa

1463

17

3.25

5.22

1.54

1.97

NCAN

Neurocan, involved in the modulation of cell adhesion and migration.

3797

18

3.86

2.98

2.56

1.56

KIF3C

Neurospecific KIF3C kinesin family member 3

29106

19

4.83

2.81

2.50

1.51

SCG3

Secretogranin III, a neuroendocrine secretory protein

81551

20

3.44

2.41

1.85

2.67

STMN4

Stathmin-like 4, regulation of the microtubule cytoskeleton


The top twenty genes based on the integrative MAX scoring are displayed. Besides the consolidated rank, the MAX values for the single data sets are also presented.

Russ and Futschik BMC Genomics 2010 11:305   doi:10.1186/1471-2164-11-305

Open Data