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Open Access Research article

Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major

Susanne Kramer*, Nicola C Kimblin and Mark Carrington

Author Affiliations

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK

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BMC Genomics 2010, 11:283  doi:10.1186/1471-2164-11-283

Published: 5 May 2010

Additional files

Additional file 1:

Figure S1: equence logos of the C-X7-C-X5-C-X3-H and C-X8-C-X5-C-X3-H zinc fingers of Tb, Tc and Lm. Only CCCH motifs that were recognized by at least either Smart, Pfam or InterPro are included. Tc CCCH motifs present more than once due to allelic variants were not included. The sequence logos shown here were used to create the combined Tritryp sequence logos shown in Figure 1.

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Additional file 2:

Table S1: List of the Tritryp CCCH proteins. List of the Tritryp CCCH proteins, including molecular weight, class of the CCCH motif and redundant genes.

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Additional file 3:

Figure S2: Alignment of the putative TbMex67 with homologues of other organisms. A) Alignment of S. cerevisiae Mex67 with T. brucei Tb11.22.0004 B) Alignment of region of greatest identity between S. cerevisiae Mex67, Tb11.22.0004 and D. melanogaster NXF1.

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Additional file 4:

Figure S3: Alignment of the Leishmania 3'-5' exoribonuclease (LmjF34.1240) with the homologous proteins of Mus musculus.

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