Additional file 12.

Effect of 1,25(OH)2D on antioxidant and DNA protection at 6 h. Figure showing the effect of 1,25(OH)2D (100 nM, 6 h) on transcripts controlling antioxidant and DNA repair systems in RWPE1 cells. Differentially expressed transcripts (SAM, any time point, FDR<5%) were examined by time point for functional changes using GenMAPP and GSA. The GenMAPP local map for antioxidant responses to reactive oxygen (Hs_Oxidative_Stress) was identified as significantly up-regulated at 6 h. While not on this map, the up-regulation of G6PD is also relevant as this enzyme system contributes to glutathione production.

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Kovalenko et al. BMC Genomics 2010 11:26   doi:10.1186/1471-2164-11-26