Additional file 10.
Effect of 1,25(OH)2D on Wnt and Notch signaling at 6 h. Figure showing the effect of 1,25(OH)2D (100 nM, 6 h) on transcripts controlling Wnt and Notch signaling in RWPE1 cells. Differentially expressed transcripts (SAM, any time point, FDR<5%) were examined by time point for functional changes using GenMAPP and GSA. The GeneMapp local map for Wnt signaling (Hs_WNT_Signaling) was identified as significantly down regulated at 6 h. In addition, a GSA motif geneset (c3 #162) for genes containing Lef1 domains in their promoters (a Wnt pathway targeted transcription factor) was significantly down-regulated.
Format: TIFF Size: 545KB Download file
Kovalenko et al. BMC Genomics 2010 11:26 doi:10.1186/1471-2164-11-26