Assessment of differential expression after mixing ALL-16 xenografts with mouse cells (NES). A MvA plots comparing i ALL.100 (100% human ALL) (n = 8) with ALL.95 (95% human ALL) (n = 3) and ii ALL.100 with ALL.90 (90% human) (n = 6), MvA plot comparing expression differences with expression averages for all transcript clusters. Plots were generated using RMA normalised log2 signal intensities, lines represent 2-fold difference (log2 = 1). B Principle component analysis of global gene-expression profiles from ALL engrafted bone marrow, spleen tissues and cell mixtures of ALL.95 (95% human) and ALL.90 (90% human). Principle components were extracted using all transcript clusters. Four principle components were calculated, of which the first three are shown.
Samuels et al. BMC Genomics 2010 11:256 doi:10.1186/1471-2164-11-256