Open Access Research article

Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia

Amy L Samuels12, Violet K Peeva1, Rachael A Papa3, Marin J Firth24, Richard W Francis4, Alex H Beesley12, Richard B Lock3 and Ursula R Kees12*

Author Affiliations

1 Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Perth, Western Australia

2 Centre for Child Health Research, The University of Western Australia, Perth, Western Australia

3 Leukaemia Biology, Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia

4 Division of Bioinformatics and Biostatistics, Telethon Institute for Child Health Research, Perth, Western Australia

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BMC Genomics 2010, 11:256  doi:10.1186/1471-2164-11-256

Published: 21 April 2010

Additional files

Additional file 1:

Pearson correlation coefficient matrix. This file contains the Pearson correlation coefficient matrix for transcript cluster expression levels between all transcript clusters for engrafted ALL-16 xenografts and mixing of ALL-16 xenografts with mouse cells (NES).

Format: XLS Size: 39KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Transcript clusters identified as susceptible to cross-species hybridisation by experimental and in silico masking approaches. This file contains the transcript cluster identity, gene title, gene symbol, chromosomal location and method used for the detection of the 1280 transcript clusters identified as susceptible to cross-species hybridisation.

Format: XLS Size: 184KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data