Research article
High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation
- † Equal contributors
1 Neuorgenomics Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
2 Pharmaceutical Genomics Division, Translational Genomics Research Institute, Scottsdale, Arizona, 85251, USA
3 Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
4 Center for Alzheimer's Research, Sun Health Research Institute, Sun City, Arizona, USA
5 Banner Alzheimer's Institute and Department of Psychiatry, University of Arizona, Phoenix, AZ, USA
6 Arizona Alzheimer's Consortium, Phoenix, AZ, USA
7 Senior Director, Neuroscience Drug Discovery, Merck and Co Ltd., BMB8-106, 33 Avenue Louis Pasteur, Boston MA 02115, USA
8 Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC 8, Tampa, FL 33612, USA
BMC Genomics 2010, 11:25 doi:10.1186/1471-2164-11-25
Published: 12 January 2010Additional files
Additional file 1:
Total tau and 12E8 tau data for all siRNAs in the Qiagen Kinome siRNA library. All data from the kinome siRNA library screen. p Tau refers to 12E8 tau. Cumulative results columns represent the average of the three independent experiments reported.
Format: XLS Size: 520KB Download file
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