Open Access Highly Accessed Research article

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

David O Azorsa2, RiLee H Robeson16, Danielle Frost16, Bessie Meec hoovet16, Gillian R Brautigam16, Chad Dickey38, Christian Beaudry2, Gargi D Basu2, David R Holz2, Joseph A Hernandez2, Kristen M Bisanz2, Leslie Gwinn2, Andrew Grover46, Joseph Rogers46, Eric M Reiman156, Michael Hutton37, Dietrich A Stephan16, Spyro Mousses2 and Travis Dunckley16*

Author Affiliations

1 Neuorgenomics Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA

2 Pharmaceutical Genomics Division, Translational Genomics Research Institute, Scottsdale, Arizona, 85251, USA

3 Department of Neurology, Mayo Clinic, Jacksonville, FL, USA

4 Center for Alzheimer's Research, Sun Health Research Institute, Sun City, Arizona, USA

5 Banner Alzheimer's Institute and Department of Psychiatry, University of Arizona, Phoenix, AZ, USA

6 Arizona Alzheimer's Consortium, Phoenix, AZ, USA

7 Senior Director, Neuroscience Drug Discovery, Merck and Co Ltd., BMB8-106, 33 Avenue Louis Pasteur, Boston MA 02115, USA

8 Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC 8, Tampa, FL 33612, USA

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BMC Genomics 2010, 11:25  doi:10.1186/1471-2164-11-25

Published: 12 January 2010

Additional files

Additional file 1:

Total tau and 12E8 tau data for all siRNAs in the Qiagen Kinome siRNA library. All data from the kinome siRNA library screen. p Tau refers to 12E8 tau. Cumulative results columns represent the average of the three independent experiments reported.

Format: XLS Size: 520KB Download file

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