miRNA tissue expression profiles. A-C) Heatmaps show the expression (normalized, log10) of miRNAs. Each arm is represented separately, as are miRNAs in the reverse orientation (if applicable). In (A), the first 10% of the heatmap is shown. miRNAs derived from loci that are homologous to miRBase human or mouse miRNA loci are shown in (B). Completely novel miRNAs are shown in (C). The legend is valid for the 3 heatmaps. D) Each tissue expresses a distinct set of miRNAs (tissue specific miRNAs). Also, some miRNAs are specifically not expressed in certain tissues (tissue avoidant miRNAs). miRNAs are specific in both replicates and the arbitrary, but strict, cutoff of 5-fold difference in expression was applied to determine specificity and avoidance.
Linsen et al. BMC Genomics 2010 11:249 doi:10.1186/1471-2164-11-249