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Open Access Research article

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

Tove Båge1*, Johan Lindberg2, Joakim Lundeberg2, Thomas Modéer1 and Tülay Yucel-Lindberg1

Author Affiliations

1 Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden

2 School of Biotechnology, Department of Gene Technology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden

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BMC Genomics 2010, 11:241  doi:10.1186/1471-2164-11-241

Published: 15 April 2010

Additional files

Additional file 1:

List of differentially expressed genes at 1 h of TNFα stimulation. Genes that were differentially expressed in gingival fibroblasts due to TNFα treatment at the 1 h time point.

Format: XLS Size: 219KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

List of significant Gene Ontology (GO) categories at 1 h of TNFα stimulation. Significant GO categories due to TNFα stimulation at the 1 h time point, containing the name and number of each GO category for reference to the different worksheets of Additional file 3.

Format: XLS Size: 16KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Complete lists of differentially expressed genes in the significant GO categories at 1 h of TNFα stimulation. The differentially expressed genes of each significant GO category are listed on a separate worksheet, labeled with the GO category number.

Format: XLS Size: 197KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

List of differentially expressed genes between 1 and 3 h of TNFα stimulation. Genes that were differentially expressed in gingival fibroblasts due to TNFα treatment between the 1 h and 3 h time points.

Format: XLS Size: 166KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

List of significant Gene Ontology (GO) categories between 1 and 3 h of TNFα stimulation. Significant GO categories due to TNFα stimulation between the 1 h and 3 h time points, containing the name and number of each GO category for reference to the different worksheets of Additional file 6.

Format: XLS Size: 16KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 6:

Complete lists of differentially expressed genes in the significant GO categories between 1 and 3 h of TNFα stimulation. The differentially expressed genes of each significant GO category are listed on a separate worksheet, labeled with the GO category number.

Format: XLS Size: 206KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 7:

List of differentially expressed genes between 3 and 6 h of TNFα stimulation. Genes that were differentially expressed in gingival fibroblasts due to TNFα treatment between the 3 h and 6 h time points.

Format: XLS Size: 119KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 8:

List of significant Gene Ontology (GO) categories between 3 and 6 h of TNFα stimulation. Significant GO categories due to TNFα stimulation between the 3 h and 6 h time points, containing the name and number of each GO category for reference to the different worksheets of Additional file 9.

Format: XLS Size: 21KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 9:

Complete lists of differentially expressed genes in the significant GO categories between 3 and 6 h of TNFα stimulation. The differentially expressed genes of each significant GO category are listed on a separate worksheet, labeled with the GO category number.

Format: XLS Size: 75KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 10:

KTH HUM 34k Oligo Microarray. Additional information concerning the oligonucleotide microarray used in this study.

Format: DOC Size: 27KB Download file

This file can be viewed with: Microsoft Word Viewer

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Additional file 11:

Oligo Microarray genelist. Genelist for the oligonucleotide microarray, including probe sequences and accession numbers.

Format: XLS Size: 17.8MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data