Table 2

The regulation of transcripts and proteins of the polyamine pathway in three distinct inhibition experiments.

Annotation

PlasmoDB ID

Cyclohexylamine

(PfSpdSyn inhibition)

(This work)

DFMO/MDL73811

(PfAdoMetDC/ODC inhibition)

[9]

DFMO (ODC inhibition)

[28]


Transcript

Protein

Transcript

Protein

Transcript


Ornithine aminotransferase

PFF0435w


S-adenosylmethionine decarboxylase-ornithine decarboxylase (PfAdoMetDC/ODC)

PF10_0322

nd

nd

nd


Hypoxanthine phosphoribosyltransferase

PF10_0121

nd

nd


Uridine phosphorylase, putative

PFE0660c

nd

nd


Adenosine deaminase, putative

PF10_0289

nd

nd


Spermidine synthase

PF11_0301

nd

nd

nd


S-adenosylmethionine synthetase, putative

PFI1090w

↓*

nd


Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)

PFE1050w

↓*

nd

nd

nd


Lysine decarboxylase, putative

PFD0285c

nd

nd

nd


* = fold change between -1.5 and -2 fold

↓ = downregulated

↑ = upregulated

≈ = unchanged

nd = not determined

A large degree of overlap was observed for the response to polyamine depletion, whether PfSpdSyn, PfAdoMetDC/ODC or ODC alone were inhibited. Also, effects specific to each inhibitor could be gauged.

Becker et al. BMC Genomics 2010 11:235   doi:10.1186/1471-2164-11-235

Open Data