Table 1

Combining essentiality with selectivity

Probability of essentiality


Genes with and without paralogues

With paralogues

Without paralogues


C. elegans

(all genes)

16%

(2941/18860 genes)

11%

(656/5988 genes)

18%

(2285/12872 genes)


C. elegans (excluding genes with mammalian orthologues)

8%

(1090/13307 genes)

6%

(249/4431 genes)

9%

(841/8876 genes)


This table demonstrates the effect of excluding genes with mammalian orthologues on the probability of essentiality. Percentages shown are the number of genes with lethal RNAi (gene knock-down) phenotypes divided by the total number of genes in each category. The numbers of genes are given in brackets.

Doyle et al. BMC Genomics 2010 11:222   doi:10.1186/1471-2164-11-222

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