Additional file 3.
Prioritized list of drug targets for A. caninum and H. contortus.xls. The genes in this list are the C. elegans predicted orthologues of the A. caninum and H. contortus ESTs, as identified in the present study. Genes that correspond to validated anthelmintic drug targets are shown in bold. All the genes in this list are predicted enzymes (by GO term) and have a lethal RNAi phenotype in C. elegans. Targets were first prioritized by the essentiality weighting assigned from the present study, then by network connectivity score. "Present in mammals" is defined by having an orthologue in one or more of the mammalian species in the OrthoMCL 2.0 dataset (human, rat, mouse). Essential orthologue in yeast, drosophila or mouse: ✓ = orthologue (with no paralogues) associated with a lethal phenotype, ✘ = orthologue (with no paralogues) that had only non-lethal phenotypes recorded, ? = orthologue (with no paralogues) but no phenotype information was available. Presence of paralogues in C. elegans was determined from the OrthoMCL grouping. Presence of paralogues in A. caninum and H. contortus was determined as described in Materials and methods. The network connectivity score is the sum of all interaction scores (log-likelihood scores) for the gene in the Wormnet core network .
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Doyle et al. BMC Genomics 2010 11:222 doi:10.1186/1471-2164-11-222