Prioritizing essential nematode drug targets. This flow diagram outlines our approach to drug target prediction and prioritization for parasitic nematodes. Some steps are clear "keep or reject" decisions because the genes failing these criteria are either not easily amenable to further development or have an unacceptable probability of being essential. Other steps are used to quantitatively refine the weighting to produce a ranked list of essential drug targets.
Doyle et al. BMC Genomics 2010 11:222 doi:10.1186/1471-2164-11-222