Enrichment of promoter motifs in functional gene clusters. Many of the discovered motifs are enriched in the upstream regions of genes grouped on the basis of GO annotation and expression profiles. This enrichment is quantified by a P-value derived using hyper-geometric distribution (see methods). The pseudo-colors in the cells represent -log10 (Hypergeometric P-value). The figure shows the cluster and the motif with the highest enrichment within that cluster. Only those clusters with a minimum enrichment score of 5.0 are shown. The columns represent the gene sets derived using GO annotation and clustering with the expression data within each GO category.
Kumar et al. BMC Genomics 2010 11:208 doi:10.1186/1471-2164-11-208