Table 3

Characteristics of the proximal gene promotersa of the seven human 8q24.3 ZNF genes

Properties

ZNF7

ZNF16

ZNF34

ZNF250

ZNF251

ZNF252

ZNF517


Genomic location b

Start

146023180

146147578

145984033

146098150

145952275

146199589

145994565

End

146023872

146146948

145983392

146097511

145951559

146198940

145995192


TSS c

528

501

505

501

501

501

501

569

514

531

617

505

528

590

531

535

544

593

540

550


CpG island d

yes

yes

yes

yes

yes

yes

yes


Core promoter elements e, f

Positiong


INR

-2

no

no

no

no

no

no

no

TATA

-31

no

no

no

no

no

no

no

BRE

-37

no

no

no

no

no

no

no

INR-DPE

-2/+28

no

no

atypical

no

no

no

no

MTE

+18

atypical

atypical

yes

no

atypical

no

yes

XCPE

-8

no

yes

no

no

no

yes

no


a Promoters determined by Genomatix Gene2Promoter (see Methods); sequences given in Additional file 11

b Based on human genome hg18

c TSS positions relative to first nucleotide in the defined promoter sequence (= 1)

d As annotated in the UCSC genome browser http://genome.ucsc.edu webcite, see Additional file 12

e Elements predicted with Genomatix MatInspector (see Methods)

f Scoring: yes = within 10 bp of usual position; atypical = not at typical position, but within 50 bp; no = absent or far (>50 bp) from typical position

g Usual default starting position of the element with respect to TSS (= +1), [55]

Lorenz et al. BMC Genomics 2010 11:206   doi:10.1186/1471-2164-11-206

Open Data