Elements of the actin binding site on S1. Structured surface loops (Myopathy and Cloop, AA404-417 and 363-377), unstructured surface loops (Loops 2 and 3, AA626-651 and 568-580), and F534 and F655 in the primary hydrophobic actin contacts (AA529-560 and 652-661) are actin binding peptides. SNP residue annotation color coding corresponds to: cardiac myosin II (red), skeletal myosin II (blue), non-muscle myosin II (brown), and unconventional myosin (tan). Thirteen SNP substitution sites K370, Q371 and P378 (C-loop); R406 and K408 (Myopathy loop); F534 and F655 (primary hydrophobic contact); K570 and A572 (Loop 3), and, A621, E631, G637, and K643 (Loop 2) are depicted in gray or yellow with space filling models of the unsubstituted side chains. The yellow residue is also implicated in disease.
Burghardt et al. BMC Genomics 2010 11:172 doi:10.1186/1471-2164-11-172