The 7-stranded β-sheet (green), Switch 2, and the Switch 2 helix (blue). SNP residue annotation color coding corresponds to: cardiac myosin II (red), skeletal myosin II (blue), smooth muscle myosin II (green), non-muscle myosin II (brown), and unconventional myosin (tan). Eight SNP substitution sites at Q478, F483, N485, H494, H495, F497, E502, and K505 on the Switch 2 helix are depicted in gray or yellow with space filling models of the unsubstituted side chains. The yellow residue is also implicated in disease. Movement at Switch 2 propagates to the Switch 2 helix and to the converter domain (not shown) via the tip of the helix near K505.
Burghardt et al. BMC Genomics 2010 11:172 doi:10.1186/1471-2164-11-172