Several myosin peptides or domains identified with energy transduction of ATP hydrolysis free energy to the mechanical work of moving actin. Structured (Myopathy and Cloop, AA363-377 and 404-417) and unstructured (Loops 2 and 3, AA626-651 and 568-580) surface loops are actin binding peptides (black). The 7-stranded β-sheet (green, AA116-127, 170-180, 248-257, 265-271, 458-468, and 671-678) mediates ATP hydrolysis and actin binding affinity modulation. The Switch 2 helix (blue, AA469-509) transmits translational movement in the active site to the converter domain (red, AA716-772) where it is converted to the torque needed to rotate the lever-arm (blue, AA773-813). The SH2/SH1 hinge (silver, AA688-715) undergoes a large conformation change with lever-arm rotation. The function of SH3 (yellow, AA30-80) in energy transduction is not yet understood. Not depicted are actin-binding-peptides at two sites in the upper half of the molecule.
Burghardt et al. BMC Genomics 2010 11:172 doi:10.1186/1471-2164-11-172