Table 2

Presence of genes related to colonization, persistence or pathogenesis in the H. mustelae genome, compared to H. pylori

Trait

H. pylori locus

Orthologous H. mustelae system

Comments


Cag pathogenicity

cag PAI

absent

Cag PAI linked to severity of pathology and disease

Urease production

Urease operon (ure)

UreAB and UreAB2 loci (HMU03050-030110) and HMU13010-13020)

Contributes to acid resistance

Vacuolating cytotoxin

vacA

absent

Cytotoxicity including T-cell inhibition

Autotransporters

VacA and paralogs

10 genes including Hsr locus (Fig. S1)

Two proteins with low identity to VacA; others - function unknown

Outer membrane adhesins

Hop, Hor, Hof, Hom paralogue families

No orthologs of BabA, SabA, OipA or AlpA/B.

Three OMPs related to Hof family; function unknown; three Hor-Hom homolgues

Invasion antigen

None

CiaB HMU0700

C. jejuni homolog enhances cell invasion

Neutrophil activation

NapA

HMU1269

Activates neutrophils & contributes oxidative stress resistance

HpaA

HP0797

absent

Putative adhesin and flagellum sheath lipoprotein

Motility

Fla/Flg/Fli/Flh

Fla/Flg/Fli/Flh

Motility is required for gastric colonization

Collagenase secretion

HP0169

HMU02630

Required for H. pylori colonization of Mongolian gerbil

Adhesion/tissue damage

-

HMU00160-HMU00170 Hag/Hly

Putative haemagglutinin/haemolysin

Plasminogen binding

HP0508

HMU02820; HMU09010

Could enhance tissue damage by proteolysis


O'Toole et al. BMC Genomics 2010 11:164   doi:10.1186/1471-2164-11-164

Open Data