Research article
Functional annotation of novel lineage-specific genes using co-expression and promoter analysis
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* Corresponding author: Harris A Lewin h-lewin@uiuc.edu
1 Department of Animal Sciences, University of Illinois at Urbana-Champaign, 210 Edward R Madigan Laboratory, 1201 W Gregory Dr, Urbana, IL 61801, USA
2 Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Room 1608, Urbana, IL 61801, USA
3 Current address: SEQUENOM, Inc, 3595 John Hopkins Court, San Diego, CA 92121, USA
BMC Genomics 2010, 11:161 doi:10.1186/1471-2164-11-161
Published: 9 March 2010Additional files
Additional file 1:
Tissue expression profile of the LIVR cluster of genes. Tissue expression profile of the LIVR cluster of genes includes two of the LSTs (237NG, 5BP) and 104/208 other genes in the cluster. L_Intestine, large intestine; M_L_Node, mesenteric lymph node; S_Intestine, small intestine.
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Additional file 2:
Comparison of ANN-Spec. ab initio predicted motif PWMs with known Transfac binding site PWMs. This table displays the frequency logos of PWMs that were predicted using ANN-Spec and for known Transfac binding sites with which the predicted PWMs were significantly matched.
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Additional file 3:
Multiple alignment of 34FL with mouse SSLP-1. Multiple alignment of 34FL with mouse SSLP-1 and other secreted Ly6 domain containing proteins having 10 conserved cysteine residues. Dashes in the alignment indicate gaps, and gray shaded areas indicate conserved cysteines.
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Additional file 4:
Functions of gene products. Text file containing glossary of gene functions.
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Additional file 5:
LSTs used for clustering with tissue expression data. Initial set of 49 LSTs used as seeds to cluster the tissue expression data.
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