Interaction of miRNAs with uAUG sequences. Each predicted interaction is characterized by a 7-mer consecutive match between the indicated half of mature miRNA (5p and 3p for the 5'- and 3'-end respectively) and uAUG sequence with ΔG37 ≤ -14 kcal mol-1. Grey bars represent actual counts and white bars represent average number of counts over 1000 repetitions of miRNA shuffling. Error bars represent the standard deviations. Significant outcomes are indicated with the corresponding p-values. (A, B) Number of interactions between uAUG sequences (4009 in total) and conserved and non-conserved miRNAs (471 and 206 in total respectively) without GU wobbles (A) and with at most one GU wobble (B). (C, D) Number of interactions between conserved miRNAs and uAUG sequences (2935 conserved and 1074 non-conserved) without GU wobbles (C) and with at most one GU wobble (D).
Ajay et al. BMC Genomics 2010 11:155 doi:10.1186/1471-2164-11-155