Table 4

The ten most coherent TFBS-cluster gene signatures according to the Ingenuity softwarea

p-value


GC, ETF, AP2GAMMA, MOVB, AP2, LRF, CHCH, SP1, AP2LAPHA

Cellular Development (MCF)

4.32E-13

Organ Development (PSDF)

2.43E-14

Wnt/b-catenin Signaling(CP)

3.90E-10

CKROX, SPZ1, WT1, MZF1, MAZ, TFIII, IK

Cellular Development (MCF)

3.97E-12

Tissue Development (PSDF)

1.23E-12

Wnt/b-catenin Signaling (CF)

1.51E-05

AML, COREBINDINGFACTOR, PEBP, OSF2, AML1

Cell-To-Cell Signaling and Interaction (MCF)

5.29E-05

Hematological System Development and Function (PSDF)

3.08E-05

Immune Cell Trafficking (PSDF)

3.08E-05

CACBINDINGPROTEIN, CACD, PAX4, SREBP1

Cellular Development (MCF)

6.48E-12

Organismal Development (PSDF)

4.92E-16

Axonal Guidance Signaling (CP)

4.26E-05

HMGIY, STAT6, STAT1, NFAT

Cellular Development (MCF)

2.43E-08

Nervous System Development and Function (PSDF)

6.45E-18

Axonal Guidance Signaling (CF)

4.24E-04

CEBPDELTA, CEBPB, CEBPA

Antigen Presentation (MCF)

4.28E-04

Humoral Immune Response (PSDF)

2.98E-04

T Helper Cell Differentiation (CP)

1.61E-03

ZF5, E2F, KROX

Gene Expression (MCF)

6.32E-22

Organ Development (PSDF)

5.59E-16

Axonal Guidance Signaling (CP)

1.13E-12

ZTA, BACH2, BACH1

Antigen Presentation (MCF)

1.35E-06

Cell-mediated Immune Response (PSDF)

1.35E-06

NF-kB Signaling (CP)

1.71E-03

CREL, NFKAPPAB65

Cell-To-Cell Signaling and Interaction (MCF)

2.73E-05

Cell-mediated Immune Response (PSDF)

1.81E-06

NF-kB Signaling (CP)

4.28E-06

MAZR, ZNF219

Cellular Development (MCF)

9.61E-13

Nervous System Development and Function (PSDF)

1.23E-10

Axonal Guidance Signaling (CP)

1.40E-07


a Only the top categories with respect to p-value are given

Veerla et al. BMC Genomics 2010 11:145   doi:10.1186/1471-2164-11-145

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