BMC Genomics

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Open Access Highly Access Research article

The dynamic architecture of the metabolic switch in Streptomyces coelicolor

Kay Nieselt1*, Florian Battke1, Alexander Herbig1, Per Bruheim2,3, Alexander Wentzel2,3, Øyvind M Jakobsen3, Håvard Sletta3, Mohammad T Alam4, Maria E Merlo4,5, Jonathan Moore11, Walid AM Omara10, Edward R Morrissey11, Miguel A Juarez-Hermosillo11, Antonio Rodríguez-García7, Merle Nentwich8, Louise Thomas9, Mudassar Iqbal11, Roxane Legaie11, William H Gaze10, Gregory L Challis6, Ritsert C Jansen4, Lubbert Dijkhuizen5, David A Rand11, David L Wild11, Michael Bonin12, Jens Reuther8, Wolfgang Wohlleben8, Margaret CM Smith9, Nigel J Burroughs11, Juan F Martín7, David A Hodgson10, Eriko Takano5, Rainer Breitling4, Trond E Ellingsen3 and Elizabeth MH Wellington10*

Author Affiliations

1 Center for Bioinformatics Tübingen, Department of Information and Cognitive Sciences, University of Tübingen, Sand 14, D-72076 Tübingen, Germany

2 Department of Biotechnology, Norwegian University of Science and Technology (NTNU), Sem Sælandsvei 6-8, N-7491 Trondheim, Norway

3 Department of Biotechnology, SINTEF Materials and Chemistry, Sem Sælandsvei 2a, N-7465 Trondheim, Norway

4 Groningen Bioinformatics Centre, University of Groningen, Kerklaan 30, 9751 NN Haren, the Netherlands

5 Department of Microbial Physiology, University of Groningen, Kerklaan 30, 9751 NN Haren, the Netherlands

6 Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK

7 Instituto de Biotecnología de León, INBIOTEC, Parque Científico de León, Av. Real 1, 24006 León, Spain, and Área de Microbiología, Universidad de León, Spain

8 Department of Microbiology/Biotechnology, University of Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany

9 School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

10 Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK

11 Warwick Systems Biology Centre, University of Warwick, Coventry House, Coventry, CV4 7AL, UK

12 Microarray Facility Tübingen, Calwer Strasse 7, D-72076 Tübingen, Germany

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BMC Genomics 2010, 11:10 doi:10.1186/1471-2164-11-10

Published: 6 January 2010

Additional files

Additional file 1:

Validation of the expression data by qRT-PCR. Black lines show the array data, red lines indicate the corresponding PCR measurements.

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Additional file 2:

Description of individual genes in the clusters shown in Figures 2, 3, 4, 5, 6, 7, 8, 9. The columns specify the SCO gene identifier, the gene name (if available), a brief description of the gene's function and the normalized expression value of the corresponding microarray probe set for each time point.

Format: XLS Size: 124KB Download file

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