Figure 2.

Epiblast-streak-mesoderm subnetwork. A subnetwork of the chicken interactome returned from jActiveModules using microarray data representing the progression from the epiblast through the streak to become developing mesoderm. This subnetwork represents a co regulated unit containing196 nodes and 553 edges. Nodes are colored according to gene expression: green represents down-regulation in the primitive streak relative to the epiblast, red represents up-regulation, and white indicates a lack of expression data. Node size indicates significance of differential expression, whereby genes with lower adjusted p-values are larger. Circular nodes are nodes meeting the threshold for significance, adj. p ≤ .08, whereas rectangular nodes either have adj. p-values greater than this value or do not have expression data associated. Interactions are color-coded according to interaction type: blue = protein-protein, yellow = gene expression, dark green = genetic interaction, and light green = part of enzymatic compound. Interactions that are direct are solid lines, whereas dashed lines indicate indirect interactions.