Table 2 |
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|
The 92 annotated genes in piglet spleen following HPS infectiona |
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|
Functional classification |
Gene Discriptionb |
GenBank ID |
FCc |
p-valued |
|
|
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|
Inflammatory response |
Resistin |
NM_020415 |
25.9 |
2.70E-02 |
|
S100 calcium binding protein A9 |
NM_002965 |
21.8 |
1.60E-03 |
|
|
S100 calcium binding protein A12 |
NM_005621 |
16.6 |
1.29E-02 |
|
|
S100 calcium binding protein A8 |
NM_002964 |
8.4 |
2.29E-02 |
|
|
Chitinase 3-like 1 |
NM_001276 |
6.3 |
1.45E-02 |
|
|
Calpain; small subunit 1 |
NM_001003962 |
5.7 |
2.50E-03 |
|
|
Interleukin 1 receptor accessory protein |
NM_002182 |
4.6 |
6.00E-04 |
|
|
Complement component 3 |
NM_000064 |
3.3 |
4.51E-02 |
|
|
Solute carrier family 2, member 3 |
3.3 |
4.05E-02 |
||
|
Interleukin 10 receptor; beta |
2.8 |
3.47E-02 |
||
|
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
2.6 |
2.24E-02 |
||
|
Histone deacetylase 9 |
0.5 |
7.00E-04 |
||
|
Chemokine (C-C motif) ligand 5 |
0.4 |
3.30E-03 |
||
|
Acute-phase response |
Serum amyloid A1 |
23.9 |
1.35E-02 |
|
|
Lactotransferrin |
13.0 |
2.26E-02 |
||
|
Angiotensinogen |
10.2 |
6.50E-03 |
||
|
Haptoglobin |
10.0 |
1.36E-02 |
||
|
Ceruloplasmin/ferroxidase |
4.9 |
4.09E-05 |
||
|
Humoral immune response |
CD163 antigen |
4.6 |
3.56E-02 |
|
|
Extracellular matrix protein 1 |
2.7 |
9.90E-03 |
||
|
Lysozyme |
2.3 |
4.20E-03 |
||
|
CD2 (cytoplasmic tail) binding protein 2 |
0.4 |
2.79E-02 |
||
|
Cell differentiation |
Transglutaminase 1 |
22.3 |
1.62E-02 |
|
|
Membrane-spanning 4-domains; subfamily A; member 8B |
20.5 |
1.61E-02 |
||
|
Cystatin A |
13.1 |
3.78E-02 |
||
|
Serpin peptidase inhibitor, clade E, member 2 |
3.6 |
2.74E-02 |
||
|
Secreted frizzled-related protein 1 |
2.3 |
3.23E-02 |
||
|
Growth arrest and DNA-damage-inducible; gamma |
2.0 |
2.79E-02 |
||
|
Carnitine deficiency-associated; expressed in ventricle 1 |
0.4 |
2.24E-02 |
||
|
Myeloid leukemia factor 1 |
0.4 |
1.61E-02 |
||
|
Stathmin-like 2 |
0.2 |
4.11E-02 |
||
|
Mal; T-cell differentiation protein |
0.2 |
2.82E-02 |
||
|
Cell adhesion |
Claudin 3 |
9.7 |
2.34E-02 |
|
|
Chondroitin sulfate proteoglycan 2/versican |
9.3 |
7.50E-03 |
||
|
Lectin, galactoside-binding, soluble, 8 |
2.8 |
7.10E-03 |
||
|
CD44 antigen |
2.5 |
5.50E-03 |
||
|
Immunoglobulin superfamily containing leucine-rich repeat |
2.3 |
3.44E-02 |
||
|
Discs; large homolog 5 |
2.2 |
2.05E-02 |
||
|
Thrombospondin 1 |
2.2 |
3.49E-02 |
||
|
Collagen; type XV; alpha 1 |
2.0 |
1.03E-02 |
||
|
Nephronophthisis 1 |
0.5 |
2.18E-02 |
||
|
Nuclear receptor subfamily 3; group C; member 2 |
0.4 |
3.18E-02 |
||
|
Fibronectin leucine rich transmembrane protein 3 |
0.4 |
3.62E-02 |
||
|
PDZ domain containing 2 |
0.3 |
8.10E-03 |
||
|
Response to oxidative stress |
Superoxide dismutase 2; mitochondrial |
3.8 |
6.10E-03 |
|
|
Dual specificity phosphatase 1 |
2.1 |
2.05E-02 |
||
|
Homeostasis |
Transcobalamin I |
17.7 |
3.06E-02 |
|
|
Solute carrier organic anion transporter family, member 2A1 |
3.0 |
5.00E-04 |
||
|
ATP-binding cassette, sub-family A (ABC1), member 5 |
2.6 |
2.48E-02 |
||
|
Transcription factor |
Zinc finger and BTB domain-containing protein 16 |
5.6 |
9.20E-03 |
|
|
CCAAT/enhancer binding protein (C/EBP), delta |
4.7 |
4.59E-02 |
||
|
Solute carrier family 39 (zinc transporter), member 14 |
4.5 |
3.66E-02 |
||
|
CCAAT/enhancer binding protein (C/EBP), beta |
3.1 |
3.00E-02 |
||
|
Nuclear factor; interleukin 3 regulated |
2.3 |
4.70E-03 |
||
|
Response to wounding |
Macrophage stimulating 1 |
2.9 |
3.31E-02 |
|
|
Coagulation factor III |
2.8 |
1.74E-02 |
||
|
Annexin A8 |
2.4 |
4.19E-02 |
||
|
Coagulation factor XIII; A1 polypeptide |
2.4 |
4.59E-02 |
||
|
Other responses to stimulus |
GTP binding protein overexpressed in skeletal muscle |
3.6 |
1.73E-02 |
|
|
Period homolog 1 |
2.6 |
7.50E-03 |
||
|
Interleukin 4 receptor |
2.2 |
2.57E-02 |
||
|
Major histocompatibility complex; class II; DR beta 1 |
0.5 |
4.18E-02 |
||
|
Guanylate binding protein 1; interferon-inducible; 67 kDa |
0.5 |
8.70E-03 |
||
|
DnaJ |
0.5 |
3.60E-03 |
||
|
Pituitary tumor-transforming 1 |
0.5 |
5.00E-04 |
||
|
Potassium voltage-gated channel; subfamily H |
0.5 |
4.33E-02 |
||
|
Major histocompatibility complex; class I; B |
0.3 |
6.00E-04 |
||
|
Development |
Cofilin 1 |
19.4 |
3.18E-02 |
|
|
P8 protein |
5.4 |
1.57E-02 |
||
|
Neuron navigator 1 |
3.4 |
1.92E-02 |
||
|
apolipoprotein D |
2.6 |
8.00E-03 |
||
|
Protein tyrosine phosphatase; non-receptor type 1 |
2.3 |
4.58E-02 |
||
|
Putative insulin-like growth factor II associated prote |
2.2 |
2.60E-03 |
||
|
FYVE; RhoGEF and PH domain containing 4 |
2.2 |
4.74E-02 |
||
|
Slingshot homolog 2 |
2.2 |
3.00E-04 |
||
|
3-phosphoadenosine 5-phosphosulfate synthase 2 |
2.1 |
2.89E-02 |
||
|
Epimorphin |
0.5 |
4.16E-02 |
||
|
Chondrolectin |
0.5 |
2.66E-02 |
||
|
Ecotropic viral integration site 5 |
0.5 |
1.52E-02 |
||
|
SMAD; mothers against DPP homolog 5 |
0.5 |
4.20E-02 |
||
|
Stearoyl-CoA desaturase |
0.5 |
1.16E-02 |
||
|
Ankyrin 3, node of Ranvier |
0.5 |
9.40E-03 |
||
|
Insulin-like growth factor 2 |
0.4 |
1.76E-02 |
||
|
SRY |
0.4 |
4.06E-02 |
||
|
Chromosome 11 open reading frame 8 |
0.4 |
3.25E-02 |
||
|
Actin; alpha; cardiac muscle |
0.3 |
8.10E-03 |
||
|
Cellular retinoic acid binding protein 1 |
0.1 |
4.34E-02 |
||
|
Erythroid associated factor |
0.01 |
6.70E-03 |
||
|
Urea cycle |
Arginase; type II |
2.1 |
1.41E-02 |
|
|
Arginase; type I |
0.2 |
2.53E-02 |
||
|
Organismal physiological process |
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F |
5.2 |
2.00E-04 |
|
|
Uridine phosphorylase 1 |
4.4 |
1.94E-02 |
||
|
|
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|
aUp/down-regulated genes which putative functions assigned based on GO term and manual annotation. Manual annotations were listed in italics. Many genes could be classified into multiple categories but only the most specific biology processes were listed. bTop informative BLASTX hit. cFold change, gene expression level following infection compared to the control. "≥2" represents up regulation (infection/control), "≤0.5" represents down regulation. d Significance level of differential expression for a particular gene. |
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|
Chen et al. BMC Genomics 2009 10:64 doi:10.1186/1471-2164-10-64 |
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