Canine osteosarcoma can predict genes linked to an aggressive phenotype in human osteosarcoma. High expression of two of four "dog-like" genes A. IL-8 (p = 0.0201) and B. SLC1A3 (p = 0.0264) were linked to poor outcome in a distinct population of 34 human osteosarcoma patient samples using Kaplan Meier analysis. IL-8's impact on outcome was evaluated according its median expression (Low (0-50) equivalent to < median expression; High (51-100) equivalent to > median expression); whereas SLC1A3 was assessed according to quartile expression (Lower (0-74) equivalent to < highest quartile expression; Highest (75-100) equivalent to highest quartile expression).
Paoloni et al. BMC Genomics 2009 10:625 doi:10.1186/1471-2164-10-625