Overall expression changes in gastric tumors of C2mE-related transgenic mice are most similar to those in human gastric cancers. K19-C2mE, K19-Wnt1/C2mE, and K19-Nog/C2mE mouse gastric tumors and human gastric (diffuse, intestinal, and mixed type), colon, breast, and lung cancers were plotted by principal component 1 to 3 (PC1 to PC3) calculated using 1,925 genes which were changed by more than two-fold in more than 50 samples of all. The cumulative contribution of the three components was 32%. Dots shown in blue: human gastric cancers; cyan: human colon cancers; red: human lung cancers; green: human breast cancers; magenta: mouse model tumors.
Itadani et al. BMC Genomics 2009 10:615 doi:10.1186/1471-2164-10-615