Research article
Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites
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* Corresponding author: Yuh-Hwa Wang ywang@wfubmc.edu
1 Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1016, USA
2 Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS 66045-7612, USA
BMC Genomics 2009, 10:59 doi:10.1186/1471-2164-10-59
Published: 30 January 2009Additional files
Additional file 1:
Comprehensive list of gene pairs involved in cancer-specific recurrent translocations which result in fusion transcripts. The translocation name(s) for each unique set of genes and the chromosomal locations of all genes are indicated. Genes which co-map to fragile sites are highlighted in gray, and the fragile site is specified.
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Additional file 2:
Gene pairs involved in cancer-specific recurrent translocations in which the breakpoint in one gene co-localizes with a fragile site. The translocation name(s) for each unique gene set is indicated. The gene within each set located at a fragile site is highlighted in gray, and the cancer(s) in which the fusion transcript is found is included.
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Additional file 3:
The computed lowest free energy of predicted DNA secondary structures. The flanking 125 kb regions are shaded in light gray, and the gene region is shaded in black. The black box indicates the location of the most stable structure found in the sequence. The black line is the curve which best fits the raw data. These curves were generated using the polyfit function of the Matlab program, and are presented in Figure 2A.
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