Research article
Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts
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* Corresponding authors: Nicholas R Casewell n.r.casewell@bangor.ac.uk - Simon C Wagstaff simonw@liv.ac.uk
1 School of Biological Sciences, Bangor University, Environment Centre Wales, Bangor, UK
2 Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, UK
BMC Genomics 2009, 10:564 doi:10.1186/1471-2164-10-564
Published: 30 November 2009Additional files
Additional file 1:
Summary statistics following clustering and assembling of ESTs for E. coloratus, E. p. leakeyi and E. c. sochureki.
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Additional file 2:
Catalogue of venom toxin encoding ESTs determined from the Echis vgDbESTs. Putative novel venom toxins are in bold and underlined. Key - SVMP: snake venom metalloproteinases; PI, PII, PIII, PIV: respective sub-group of SVMPs; ND: sub-class not determined; DIS: short coding disintegrins; CTL: C-type lectins; PLA2: group II phospholipases A2; SP: serine proteases; LAO: L-amino oxidases; CRISP: cysteine-rich secretory proteins; VEGF: vascular endothelial growth factors; NGF: nerve growth factors; PEPT: peptidases; AP: aminopeptidase; DPP: dipeptidyl peptidase III; NEP: neprilysin; PE: Purine liberators; PHOS: phosphdiesterase; 5'-NUC: 5'-nucleotidase; E-NTPase: ectonucleoside triphosphate diphosphohydrolase; LAL: lysosomal acid lipases; RLAP: renin-like aspartic proteases; HYAL: hyaluronidases; KTZ: kunitz-type protease inhibitors.
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Additional file 3:
An overview of clustering processes for three species of the genus Echis. The graph demonstrates the percentage of ESTs that are added to clusters (ESTs >1) as the cumulative number of ESTs entering the database increase. In all species the number of ESTs affecting the proportion of EST clusters and singletons reaches a plateau after 800 sequences.
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